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Scientific Program + Slides

 

Monday, September 24, 2012
12:00
13:30
Registration
13:30
17:00
Tutorial: Bayesian Statistics in the NonClinical AreaBruno Boulanger and Pierre
Lebrun (material together
with Emmanuel Lesaffre)
17:00
19:00
Establishment of European Working Group
Statistical approaches for Anti-DrugAntibody (ADA) identificationLudwig Hothorn
19:00
21:00
Poster Session & Welcome Reception
Variability and transfer of analytical
methodsMisbah Ahmed
Mixed effect modeling for the identification
of pharmacodynamic markers for cancer
treatment in a multi-technology approachSabine Bader, C.-H. Ooi, B. Bossenmaier,
T. Friess, M.Thomas
Discussion Forum: European working
groups in non-clinical statisticsCatherine Hessler
Tuesday, September 25, 2012
08:45
09:00
WelcomeRichardus Vonk
09:00
10:30
Session: Dose ResponseChristian Ritz
State of the art in dose-response modellingJens Streibig, Christian Ritz
Dose-response curves in industrial
biotechnologyThomas Agersten Poulsen
Automating non-clinical statistics using the
R Service Bus. The case of dose response
modelingTobias Verbeke
10:30
11:00
Break
11:00
12:30
Session BioassaysEmmanuel Pham
An evaluation of methods for determining
confirmatory cut-points in enzyme-linked
immunosorbent assays (ELISA)Thomas Jaki
Assessing the performance of statistical
methods for estimating a common relative
potency in bioassaysThembile Mzolo, Edwin van
den Heuvel, Marga Hendricks
Comparison of Hemacytometer and HiRes
cell counters used in potency assaysPriya Kulkarni, Bill Forrest
Which method to estimate Kd and Ki in
fluorescence polarization?Dorothée Tamarelle,
Armel Salangros
12:30
14:00
Lunch Break
14:00
15:30
Session Bayesian ApproachesBruno Boulanger
Use of a 3 steps bayesian approach for the
Behrens-Fisher problem in pre-clinical
experimentsKarine Florin, Jean Michel
Marin, Antoine Barbieri,
Marouane Seffal
Bayesian approach to risk assessment for
dissolution testing of a marketed drug
productCoppenolle Hans, Altan Stan,
Chen Juan, Manola Areti,
Shen Yan, Shoung Jyh-Ming
Bayesian analysis of analyte dataJohn Whittaker, Linda
Warnock
A Design Space to guarantee the long-term
stability of a new formulation given
production constraints: a Bayesian
perspective.Bruno Boulanger, Pierre Lebrun
A Bayesian model for filling of a product to
reduce risk of being OOS in presence of
uncertainty.Bruno Boulanger, Pierre Lebrun
15:30
16:00
Break
16:00
18:00
Session QSTARLuc Bijnens
Quantitative Structure Transcriptional
Activity Relationship (QSTAR)Luc Bijnens, Willem Talloen
Development of predictive models and
feature selection using LASSO and elastic
netPushpike Thilakarathne,
Martion Otava, Nolen Joy
Perualila, Tatsiana
Khamiakova, Adetayo
Kasim, Ziv Shkedy
Analoging in large databases with structural
fingerprint featuresMartin Heusel, Andreas
Mayr, Günter Klambauer,
Andreas Mitterecker, Ulrich
Bodenhofer, Djork-Arné
Clevert, Sepp Hochreiter
Integrated analysis of microarray data,
biological data and chemical data in drug
developmentNolen Joy Perualila,
Pushpike Thilakarathne,
Martion Otava, Tatsiana
Khamiakova, Adetayo
Kasim, Ziv Shkedy
Biclustering in drug designDjork-Arné Clevert, Günter
Klambauer, Andreas Mayr,
Andreas Mitterecker, Ulrich
Bodenhofer, Martin Heusel,
Sepp Hochreiter
Integrated statistical analysis of three data
sources for the detection of chemical
fingerprint features that are simultaneously
associated with bio-assay and
transcriptomics data.Alain Visscher, Federico
Mattiello, Olivier Thas
18:00
22:00
Social Event
Wednesday, September 26, 2012
08:30
09:00
Session ManufacturingBruno Boulanger
The use of multiple linear regression to find
acceptable ranges for manufacturing
materialsMike Aylott
Practical applications of statistical process
controlKatharina Schiffl
09:00
10:30
Session ToxicologyLudwig Hothorn
Identification of the LOAEL by a model
selection procedureLudwig Hothorn, Kuiper,
RM, Gerhard, D
Evaluation of statistical methods to
construct confidence intervals for the lowest
observed effect concentrationXiaoqi Jiang
A novel method to estimate the minimum
effective dose for monotone and nonmonotone dose-response relationshipsMartin Wolfsegger
Normalizing to control measurements in
dose-response studies: What is the effect on
parameter estimates?Annette Kopp-Schneider,
Xiaoqi Jiang, Oriana Ponta,
Sven Stanzel, Alexius
Freyberger, Marc Weimer
Statistical planning and analysis of the HETMN Assay for genotoxicity testingRalph Pirow, Dagmar
Fieblinger, Manfred Liebsch,
Albrecht Poth, Kerstin
Reisinger, Thorsten Wolf,
Daniel Gerhard,
Ludwig Hothorn
Stochastic models for brain aggregate cell
cultures: Quantitative description of
neurotoxicityMaria Renner, Annette Kopp-Schneider
10:30
11:00
Break
11:00
12:30
Session Animal to Human TranslationKatja Remlinger
Trends in translational sciences: Role of
industrial-academic collaborationKhusru Asadullah
Difficulties in Translation from Animal to
Man – Some Examples from Neuroscience
ResearchDavid Willé
Translation of Pre-Clinical Pharmocokinetic
Parameters in the Determination of Dosing
in First Time in Human StudiesAlun Bedding
Panel / Audience DiscussionKatja Remlinger
12:30
13:30
Break
13:30
15:30
Session VariousRichardus Vonk
Estimation of in-vitro dose response curves
in the presence of drug resistant viral
mutationsDoreen Abainenamar, T.
Jacobs, H. Ceulemans, O.
Lenz, G. Molenberghs, T.
Verbinnen.
Detecting pharmacodynamic drug-drug
interactions – a pharmacometric success
storyTom Jacobs, C. Mackie, W.
Talloen, T. Steckler, A.
Megens
Quantitative assessment of drug interactions
by linear mixed effects modelingSven Stanzel, Helene Bayer,
Annette Kopp-Schneider
Normal ranges determination with quantile
regressionLuc Esserméant
Logistic regression re-modelledTina Müller,
Hannes Friedrich Ulbrich
Quasi-species identification with model
based clusteringBie Verbist , Koen Van der
Borght, Yves Wetzels , Kim
Thys, Joke Reumers, Tobias
Verbeke, Willem Talloen,
Joris Meys, Carl Van Hove,
Jeroen Aerssens, Luc
Bijnens, Olivier Thas
Biophysical rationale and quantitative
benefits of using linear mixed effect models
to summarize transitions of peptides to
protein abundances in SRMJens Lamerz, Paul Cutler,
Anton Belousov, G.
Duchateau-Nguyen
15:30
15:45
CloseRichardus Vonk

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