| Tuesday, 28 September 2010 |
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Welcome - Main Conference |
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E. Pham |
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| Session 1 |
Assays |
Chair: Richardus Vonk |
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Improving statistical quality in published research: the clinical experience |
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Professor Martin Bland,
Department of
Health Sciences,
University of York, UK |
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Contributed papers |
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Statistical analysis of analytical method transfer: proposals for the location-scale approach and tolerance
intervals |
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Cornelia Frömke |
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Development and Validation of an in-vivo bioassay |
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Birgit Niederhaus |
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Cut-off determination: can prediction limit
be used as an
alternative to the 95% percentile? |
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Marion Berger |
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Statistical methods for cut-point determination in enzyme- linked immunosorbent assays
(ELISA) |
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Thomas Jaki |
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Use of parametric model-averaging in dose-response analysis |
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Christian Ritz |
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Comparison of initial value routines for dose-response models |
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Anke Schulz |
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| Session 2A |
Bayesian Statistics |
Chair: Bruno Boulanger |
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Contributed papers |
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Use of Bayesian inference in ecotoxicology |
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Sandrine Charles |
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Optimization of ligand-binding assay in a
QbD
environment: Use of Bayesian non-linear hierarchical
model to set up precision profile as quality response. |
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Pierre Lebrun |
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A Bayesian approach to predicting precision of a future study in the presence of uncertainty about the variance |
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John Sherington |
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Bayesian modelling of Escherichia coli O157:H7 dose response incorporating age as a covariable |
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Marie Laure Delignette-Muller |
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| Session 3A |
Methodology (I) |
Chair: Viswanath Devanaryan |
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Contributed papers |
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Probabilistic modeling for risk assessment
of residual host
cell DNA in biological products |
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Harry Yang |
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Steady-State zone and control chart for
process parameters
of a powder compactor . |
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Caroline Lévéder |
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Design Space – Risk Based Approach |
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Kevin Lief |
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Assessing quality control for repeated
bioassay data by
parametric and non-parametric prediction intervals |
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Daniel Gerhard |
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| Session 4A |
Methodology (II) |
Chair: Harry Yang |
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Contributed papers |
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How to accept the equivalence of two
measurement
methods? Comparison and improvements of the Bland
and
Altman’s approach and errors-in-variables regression. |
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Bernard Francq |
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Characterizing in vitro synergy using the
ray design
methodology |
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Sophie Ruquet |
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| Session 2B |
Toxicology (I) |
Chair: Ludwig Hothorn |
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Contributed papers |
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Comet Analysis – Issues, Limitations and Recommendations |
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Jonathan Bright |
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Comet Assays – Facts and Figures |
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Luc Essermeant |
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An Overview of the Toxicology SIG |
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Mike Aylott |
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Testing a trend effect for count variables
which are bounded by another count variable: application to fertility counts |
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Jean-Paul Lahmy |
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| Session 3B |
Toxicology (II) |
Chair: Yi Tsong |
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Contributed papers |
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Assessing systemic drug exposure in
repeated dose toxicity studies in the case of
complete and
incomplete sampling |
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Martin J. Wolfsegger |
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Williams-type procedure on monotone trend
for normal, non-normal, ordered categorical, proportion and
poly-k data, with application in toxicology |
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Ludwig Hothorn |
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A Step-Down Approach to Analyzing
Electrocardiogram Endpoints For In Vivo Regulatory Toxicology Studies |
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Maya L Hanna |
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Concentration-response analysis of a
stochastic process: Multi-state modelling of in-vitro
folliculogenesis and
oocyte maturation |
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Marc Weimer |
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Optimization of the irinotecan – efflux
transporter inhibitors combination for treating irinotecan
resistant
tumours |
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Alexandre Sostelly |
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Anova-Type Statistics, a good alternative to
parametric methods for analysing repeated data from preclinical
experiments |
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Odile Coudert-Berthion |
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Prediction of tumor class from gene
expression data using bagged decision trees |
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Sam Roberts |
| Wednesday, 29 September 2010 |
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| Session 4bis |
Translational sciences |
Chair: Emmanuel Pham |
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Development of a dose content uniformity test suitable for medium and large sample sizes |
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Yi Tsong, Deputy director, Office of
Biostatistics, CDER, FDA, USA |
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Contributed papers |
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K-PD models as a flexible modeling tool in non-clinical statistics |
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Tom Jacobs |
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A Unified Approach to Flexible and Powerful Modeling Of Pre-Clinical Combination Studies |
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Chris Harbron |
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Pharmacokinetic similarity analysis using nonlinear mixed effects models |
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Anne Dubois |
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Modeling Dose-response Microarray Data in Early Drug Development Experiments |
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Dan Lin |
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A multivariate analysis of prognostics factors in Chronic Lymphocytic Leukemia |
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Giuseppe Palermo |
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Genomic Biomarkers for Depression: feature-specific and joint biomarkers |
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Helena Geys |
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| Session 5 |
Omics |
Chair: Luc Bijnens |
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Development of biomarker signatures from
high- dimensional array data, and identification of subsets with common patterns between multiple array platforms |
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Viswanath Devanaryan, Director
Exploratory Statistics, Abbott Laboratories, USA |
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Contributed papers |
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Multivariate approaches to develop molecular biomarkers: a reality check. |
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Willem Talloen |
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Seeing the Wood for the Trees:
Interrogating the Structure of Random Forests |
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Chris Harbron |
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Testing for the Differential
Expression of Genes at the Probe Level of Affymetrix Microarray data |
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Tatsiana Khamiakova |
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Treatment of Genomic Data in the Context of Macroarrays |
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Julie Pouget |
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Addressing the Challenges of the
Analysis of Genomics Data with JMP Genomics |
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Valerie Nedbal |
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Closing and concluding remark |
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Luc Bijnens and E. Pham |
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